Our Publications

See our publications in PubMed or Google Scholar:

Poly(A)-binding protein is an ataxin-2 chaperone that regulates biomolecular condensates.

Boeynaems S, Dorone Y, Zhuang Y, Shabardina V, Huang G, Marian A, Kim G, Sanyal A, Şen NE, Griffith D, Docampo R, Lasker K , Ruiz-Trillo I, Auburger G, Holehouse AS, Kabashi E, Lin Y, Gitler AD. Mol Cell. 2023 Jun 15;83(12):2020-2034.e6. DOI: 10.1016/j.molcel.2023.05.025.

Machine-learning-based methods to generate conformational ensembles of disordered proteins.

Taneja I, Lasker K. Biophys J. 2024 Jan 2;123(1):101-113. DOI: 10.1016/j.bpj.2023.12.001.

Aberrant phase separation is a common killing strategy of positively charged peptides in biology and human disease

Boeynaems S, Ma XR, Yeong V, Ginell GM, Chen JH, Blum JA, Nakayama L, Sanyal A, Briner A, Van Haver D, Pauwels J, Ekman A, Schmidt HB, Sundararajan K, Porta L, Lasker K, Larabell C, Hayashi MAF, Kundaje A, Impens F, Obermeyer A, Holehouse AS, Gitler AD. BioRxiv. 2023. DOI:10.1101/2023.03.09.531820

Integrative visualization of the molecular structure of a cellular microdomain.

Goodsell D, Lasker K.
Protein Sci. 2023. DOI:10.1002/pro.4577

The material properties of a bacterial-derived biomolecular condensate tune biological function in natural and synthetic systems

Lasker K*, Boeynaems S*, Lam V, Scholl D, Stainton E, Briner A, Jacquemyn M, Daelemans D, Deniz A, Villa E, Holehouse AS, Gitler A, Shapiro L.
Nat Commun . 2022. DOI:10.1038/s41467-022-33221-z

Generative modeling of short, disordered proteins with homogeneous sequence composition

Taneja I, Lasker K*.
BioRxiv . 2022. DOI:10.1101/2022.11.11.516154

Poly(A)-binding protein is an ataxin-2 chaperone that emulsifies biomolecular condensates

Boeynaems S, Dorone Y, Marian A, Shabardina V, Huang G, Kim G, Sanyal A, Şen N-E, Docampo R, Ruiz-Trillo I, Lasker K, Auburger G, Kabashi E, Gitler AD.
BioRxiv. 2021. DOI: 10.1101/2021.08.23.457426

ATAC-seq reveals megabase-scale domains of a bacterial nucleoid

Melfi MD, Lasker K, Zhou X, Shapiro L
BioRxiv. 2021. DOI:10.1101/2021.01.09.426053

The In Situ Structure of Parkinson's Disease-Linked LRRK2.

Watanabe R, Buschauer R, Böhning J, Audagnotto M, Lasker K, Lu TW, Boassa D, Taylor S, Villa E.
Cell. 2020; 182 (6), 1508-1518. PMID: 32783917

Selective sequestration of signalling proteins in a membraneless organelle reinforces the spatial regulation of asymmetry in Caulobacter crescentus.

Lasker K*, von Diezmann L*, Zhou X, Ahrens DG, Mann TH, Moerner WE, Shapiro L.
Nat Microbiol. 2020; 5(3):418-429. PMID: 31959967

A Localized Complex of Two Protein Oligomers Controls the Orientation of Cell Polarity.

Perez AM, Mann TH, Lasker K, Ahrens DG, Eckart MR, Shapiro L.
mBio. 2017; 8(1):e02238-16. PMID: 28246363

An intracellular compass spatially coordinates cell cycle modules in Caulobacter crescentus.

Lasker K*, Mann TH*, Shapiro L.
Curr Opin Microbiol. 2016; 33:131-139. PMID: 27517351

Cell cycle progression in Caulobacter requires a nucleoid-associated protein with high AT sequence recognition.

Ricci DP, Melfi MD, Lasker K, Dill DL, McAdams HH, Shapiro L.
Proc Natl Acad Sci U S A. 2016;113(40):E5952-E5961. PMID: 27647925

CauloBrowser: A systems biology resource for Caulobacter crescentus.

Lasker K, Schrader JM, Men Y, Marshik T, Dill DL, McAdams HH, Shapiro L.
Nucleic Acids Res. 2016;44(D1):D640-5. PMID: 26476443

Peptide dimer structure in an Aβ(1-42) fibril visualized with cryo-EM.

Schmidt M, Rohou A, Lasker K, Yadav JK, Schiene-Fischer C, Fändrich M, Grigorieff N.
Proc Natl Acad Sci U S A. 2015;112(38):11858-63. PMID: 26351699

Topological models of heteromeric protein assemblies from mass spectrometry: application to the yeast eIF3:eIF5 complex.

Politis A, Schmidt C, Tjioe E, Sandercock AM, Lasker K, Gordiyenko Y, Russel D, Sali A, Robinson CV.
Chem Biol. 2015;22(1):117-28. PMID: 25544043

The coding and noncoding architecture of the Caulobacter crescentus genome.

Schrader JM, Zhou B, Li GW, Lasker K, Childers WS, Williams B, Long T, Crosson S, McAdams HH, Weissman JS, Shapiro L.
PLoS Genet. 2014;10(7):e1004463. PMID: 25078267

Finding the right fit: chiseling structures out of cryo-electron microscopy maps.

Villa E, Lasker K.
Curr Opin Struct Biol. 2014;25:118-25. PMID: 24814094

Modeling of proteins and their assemblies with the Integrative Modeling Platform.

Webb B, Lasker K, Velázquez-Muriel J, Schneidman-Duhovny D, Pellarin R, Bonomi M, Greenberg C, Raveh B, Tjioe E, Russel D, Sali A.
Methods Mol Biol. 2014;1091:277-95. PMID: 24203340

Conformational transitions in human translin enable nucleic acid binding.

Pérez-Cano L, Eliahoo E, Lasker K, Wolfson HJ, Glaser F, Manor H, Bernadó P, Fernández-Recio J.
Nucleic Acids Res. 2013;41(21):9956-66. PMID: 23980029

Assembly of macromolecular complexes by satisfaction of spatial restraints from electron microscopy images.

Velázquez-Muriel J, Lasker K, Russel D, Phillips J, Webb BM, Schneidman-Duhovny D, Sali A.
Proc Natl Acad Sci U S A. 2012;109(46):18821-6.PMID: 23112201

Macromolecular assembly structures by comparative modeling and electron microscopy.

Lasker K, Velázquez-Muriel JA, Webb BM, Yang Z, Ferrin TE, Sali A.
Methods Mol Biol. 2012;857:331-50. PMID: 22323229

Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.

Lasker K*, Förster F*, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W.
Proc Natl Acad Sci U S A. 2012; PMID: 22307589

Putting the pieces together: integrative modeling platform software for structure determination of macromolecular assemblies.

Russel D, Lasker K, Webb B, Velázquez-Muriel J, Tjioe E, Schneidman-Duhovny D, Peterson B, Sali A.
PLoS Biol. 2012;10(1):e1001244. PMID: 22272186

The proteasomal subunit Rpn6 is a molecular clamp holding the core and regulatory subcomplexes together.

Pathare GR, Nagy I, Bohn S, Unverdorben P, Hubert A, Körner R, Nickell S, Lasker K, Sali A, Tamura T, Nishioka T, Förster F, Baumeister W, Bracher A.
Proc Natl Acad Sci U S A. 2012;109(1):149-54. PMID: 22187461

UCSF Chimera, MODELLER, and IMP: an integrated modeling system.

Yang Z, Lasker K, Schneidman-Duhovny D, Webb B, Huang CC, Pettersen EF, Goddard TD, Meng EC, Sali A, Ferrin TE.
J Struct Biol. 2012;179(3):269-78. PMID: 21963794

Modeling of proteins and their assemblies with the integrative modeling platform.

Webb B, Lasker K, Schneidman-Duhovny D, Tjioe E, Phillips J, Kim SJ, Velázquez-Muriel J, Russel D, Sali A.
Methods Mol Biol. 2011;781:377-97. PMID: 21877292

MultiFit: a web server for fitting multiple protein structures into their electron microscopy density map.

Tjioe E, Lasker K, Webb B, Wolfson HJ, Sali A.
Nucleic Acids Res. 2011;39:W167-70. PMID: 21715383

Determining macromolecular assembly structures by molecular docking and fitting into an electron density map.

Lasker K, Sali A, Wolfson HJ.
Proteins. 2010;78(15):3205-11. PMID: 20827723

Integrative structure modeling of macromolecular assemblies from proteomics data.

Lasker K, Phillips JL, Russel D, Velázquez-Muriel J, Schneidman-Duhovny D, Tjioe E, Webb B, Schlessinger A, Sali A.
Mol Cell Proteomics. 2010;9(8):1689-702. PMID: 20507923

Toward an integrated structural model of the 26S proteasome.

Förster F, Lasker K, Nickell S, Sali A, Baumeister W.
Mol Cell Proteomics. 2010;9(8):1666-77. PMID: 20467039

An atomic model AAA-ATPase/20S core particle sub-complex of the 26S proteasome.

Förster F, Lasker K, Beck F, Nickell S, Sali A, Baumeister W.
Biochem Biophys Res Commun. 2009;388(2):228-33. PMID: 19653995

Insights into the molecular architecture of the 26S proteasome.

Nickell S, Beck F, Scheres SH, Korinek A, Förster F, Lasker K, Mihalache O, Sun N, Nagy I, Sali A, Plitzko JM, Carazo JM, Mann M, Baumeister W.
Proc Natl Acad Sci U S A. 2009;106(29):11943-7. PMID: 19581588

Inferential optimization for simultaneous fitting of multiple components into a CryoEM map of their assembly.

Lasker K, Topf M, Sali A, Wolfson HJ.
J Mol Biol. 2009;388(1):180-94. PMID: 19233204

The structural dynamics of macromolecular processes.

Russel D, Lasker K, Phillips J, Schneidman-Duhovny D, Velázquez-Muriel JA, Sali A.
Curr Opin Cell Biol. 2009;21(1):97-108. PMID: 19223165

Protein structure fitting and refinement guided by cryo-EM density.

Topf M, Lasker K, Webb B, Wolfson H, Chiu W, Sali A.
Structure. 2008;16(2):295-307. PMID: 18275820

EMatch: discovery of high resolution structural homologues of protein domains in intermediate resolution cryo-EM maps.

Lasker K, Dror O, Shatsky M, Nussinov R, Wolfson HJ.
IEEE/ACM Trans Comput Biol Bioinform. 2007;4(1):28-39. PMID: 17277411

EMatch: an efficient method for aligning atomic resolution subunits into intermediate-resolution cryo-EM maps of large macromolecular assemblies.

Dror O, Lasker K, Nussinov R, Wolfson H.
Acta Crystallogr D Biol Crystallogr. 2007;63(Pt 1):42-9. PMID: 17164525